Drug Targets: Turning the Channel (on) for Sedation
نویسندگان
چکیده
Genetic techniques have recently implicated two different ion channels as critical molecular targets for the sedative action of ethanol and intravenous anesthetics. In each case, the target is hyperactivated by the drug.
منابع مشابه
Laminar Flow Analysis in the Channel Bends
In this paper the laminar flow in the rectangular channel bends is simulated using numerical techniques. The turning angle of the channel bend and the area ratio of the channel cross-section are two important parameters to be examined. For flow simulation, the body fitted 3-D continuity and momentum equations are used and a body fitted general purpose code is developed. The existing results of ...
متن کاملLaminar Flow Analysis in the Channel Bends
In this paper the laminar flow in the rectangular channel bends is simulated using numerical techniques. The turning angle of the channel bend and the area ratio of the channel cross-section are two important parameters to be examined. For flow simulation, the body fitted 3-D continuity and momentum equations are used and a body fitted general purpose code is developed. The existing results of ...
متن کاملIdentification and Evaluation of Novel Drug Targets against the Human Fungal Pathogen Aspergillus fumigatus with Elaboration on the Possible Role of RNA-Binding Protein
Bakground: Aspergillus fumigatus is an airborne opportunistic fungal pathogen that can cause fatal infections in immunocompromised patients. Although the current anti-fungal therapies are relatively efficient, some issues such as drug toxicity, drug interactions, and the emergence of drug-resistant fungi have promoted the intense research toward finding the novel drug targets. Methods: In searc...
متن کاملNewest Targets for Anticonvulsant Agents: An Overview
Epilepsy is a neurological condition characterized by recurrent seizures influencing about 1% of the worldwide population. Despite much progress in understanding the pathogenesis of epilepsy, the molecular basis of human epilepsy still remains unclear. Common approaches for pharmacotherapy of epilepsy are still directed towards controlling the symptoms and suppression of seizures. Clinical use ...
متن کاملEffect of two Different Concentrations of Propofol and Ketamine Combinations (Ketofol) in Pediatric Patients under Lumbar Puncture or Bone Marrow Aspiration
Abstract Background Ketamine is an anesthetic drug that is importantly analgesic without respiratory depression. Ketamine increases blood pressure and heart rate. Propofol is an anesthetic drug with good sedation, rapid recovery, but it causes respiratory depression, low heart rate and low blood pressure. Combination of Ketamine and Propofol provides sedation, analgesia and rapid recovery wit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 14 شماره
صفحات -
تاریخ انتشار 2004